Acetaminophen prophylaxis of adverse reactions following vaccination of infants with diphtheria-pertussis-tetanus toxoids-polio vaccine.
MOSHE, M. IPP, MD; GOLD, RONALD MD; GREENBERG, SAUL MD; GOLDBACH, MORTON MD; KUPFERT, BEVERLY B. MD; LLOYD, DAVID D. MD; MARESKY, DAVID C. MD; SAUNDERS, NORMAN MD; WISE, SHELDON A. MD
[Article] Pediatric Infectious Disease Journal. 6(8):721-724, August 1987.

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The effect of acetaminophen on reducing the frequency and severity of adverse reactions following diphtheria-pertussis-tetanus toxoids-polio vaccine was studied in a randomized clinical trial involving 519 vaccinations in 383 infants 2 to 6 months of age and 70 infants 18 months of age. Significantly fewer local and systemic reactions were reported in acetaminophen-treated infants at 2 to 6 months of age. Acetaminophen also reduced the incidence of fever

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